ScienceWorld once did a colourful exhibition called Grossology, in which various parts of human anatomy are presented in garish, cartoony displays. The Farrelly Brother’s Osmosis Jones reminds me quite a bit of that, an inspired, juvenile little creation that seems to have slipped through the cracks. Focusing on the human body, or rather one human body in the form of out of shape, sloppy schmuck Bill Murray, it’s one of those rare half live action, half animated flicks, a concept which I love but one that only works out if you do it right. It worked magic in Who Framed Roger Rabbit, it train-wrecked in Rocky & Bullwinkle, and went more middle of the road in stuff like Cool World and The Pagemaster. Here it works pretty damn well, if a little better on the animated side, where most of the focus is put anyways. Murray is Frank, a walking disaster whose lifestyle reflects the culmination of the Farrelly’s career in terms of utmost vulgarity. Zooming inside his body, a sassy technicolor world emerges, sentient forces living in infrastructure not unlike our own, albeit peppered with so many delightful jokes, gags (some which will kick the reflex into action) and word-plays it’s hard to keep up. Chris Rock plays a lively white blood cell cop who responds when Frank eats a hard boiled egg that’s home to a deadly virus, and runs all about the City Of Frank chasing it down, joined by a robotic cherry flavoured Cold Pill (David Hyde Pierce). City Hall is Cerebellum Hall in the Brain, the bowels resemble skid row, Mafia bacteria thugs reside in the armpit, and you get the idea. The imagination runs wild here, if a little grotesque in areas. The live action bits suffer in terms of writing and realism, they just feel like a queasy SNL skit and never have enough weight. It’s non stop fun when the animation kicks in though, a slightly off-Disney style that stimulates the screen visually and pops with every colour combination you can imagine. My favourite has to be Laurence Fishburne as Thrax, the deadly virus attacking Frank’s nervous system, a gangly, evil eyed freak who sports purple dreadlocks, a contagious Freddy Krueger style index finger and enjoys his job a bit too much. William Shatner is great as sleazy Mayor Phlemming too. It’s not as much fun as stuff like InnerSpace, and the live action clashes with the animated world in places where it should seamlessly mesh, but it has one admirable quality in spades: imagination. The jokes and ideas within Frank’s body are hurled at you a mile a minute, and you’d need to watch it at least twice to catch every little barb and dad-joke worthy pun. Good times.

-Nate Hill